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Trulicity is a once-weekly injectable prescription medicine used to improve blood sugar levels in adults with type 2 diabetes, which should be taken along with diet and exercise. It helps control high blood sugar levels and may lower the risk of heart attack, stroke, or death related to heart disease. Trulicity is also shown to help with weight loss. Some common side effects of Trulicity include nausea, diarrhea, vomiting, abdominal pain, decreased appetite, indigestion, and fatigue. Dulaglutide is the active ingredient in Trulicity. It is used to control high blood sugar levels in people with type 2 diabetes. Trulicity and Ozempic are both used to treat Type 2 diabetes, but Trulicity is approved for this use in more people than Ozempic.