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Solifenacin is a medication used to treat bladder problems, specifically neurogenic detrusor overactivity and symptoms of an overactive bladder. It works by relaxing the muscles in the bladder, improving control over urination. Solifenacin is commonly prescribed to reduce the frequency of urination and manage wetting accidents. It is available in oral form under the brand name VESIcare. When taking solifenacin, it is recommended to take it at night to improve nighttime symptoms such as nocturia. It is important to exercise caution when prescribing solifenacin to patients with renal impairment, as it has been shown to have an increased half-life and AUC in such individuals. There is also evidence suggesting an increased risk of dementia in patients taking solifenacin or other bladder antimuscarinics for prolonged periods, particularly in diabetic patients. In terms of efficacy and tolerability, solifenacin 5 mg once daily is often the preferred choice as it is more effective compared to other treatments. However, it may come with more adverse effects. If solifenacin is unsuitable, oxybutynin 3 mg TDS is recommended as an alternative. In summary, solifenacin is a medication used to treat bladder problems, specifically neurogenic detrusor overactivity and symptoms of an overactive bladder. It works by relaxing the muscles in the bladder to improve control over urination. Caution should be exercised when prescribing solifenacin to patients with renal impairment, and the potential risk of dementia should be considered, especially in diabetic patients. Solifenacin 5 mg once daily is often the preferred choice due to its efficacy, but if it is not suitable, oxybutynin 3 mg TDS is recommended as an alternative.