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Safe supplement refers to dietary supplements that are verified to be safe and effective for consumption. The FDA regulates supplements to ensure they are labeled truthfully and not misleading. While most people can use supplements safely, one should be cautious with taking too much. Some supplements can increase the risk of bleeding or affect response to anesthesia. Choosing a safe supplement brand involves choosing brands labeled with the NSF International, US Pharmacopeia, Underwriters Laboratory, or Consumer Lab seal. Top safe supplement brands include Thorne Research, which partners with various research organizations to test their products via clinical trials for efficacy and safety. It is important to verify that the product actually contains the ingredients that the label says it does and doesn't have any potentially harmful ingredients.